Generic Buspar ( Buspirone )

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At our US pharmacy, you can purchase Buspar (buspirone) 5 mg and 10 mg tablets without a prescription, with discreet and anonymous packaging delivered within 5-14 days across USA.
Buspar is an anxiolytic used for the short-term relief of excessive anxiety in people with generalized anxiety disorder. It is not a benzodiazepine and does not cause the sedation or dependence that drugs like diazepam can. The medication works by bringing certain brain chemicals back into balance, though the exact mechanism is still being studied.
The usual starting dose is 5 mg two or three times daily. Your doctor may increase the dose by 5 mg every 2 to 3 days, up to a maximum of 45 mg daily in divided doses. Most people take it two or three times a day.
The administration form is scored tablets in 5 mg and 10 mg strengths. The 10 mg tablet is white and pillow-shaped, engraved with "BU 10" on one side and "APO" on the other.
Buspar does not work overnight. It may take two to four weeks before you notice a real difference in your anxiety. Do not stop taking it just because you do not feel an effect in the first few days.
Alcohol should be avoided during treatment. It can increase the sedative effect of buspirone and make drowsiness and dizziness worse. Also avoid large amounts of grapefruit juice, which can raise the level of buspirone in your body.
The most common side effects are dizziness, drowsiness, nervousness, headache, and nausea.
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Common Use Buspar

Buspirone is an anxiolytic that belongs to a class of medications called azaspirodecanediones. It is chemically unrelated to benzodiazepines, barbiturates, and other sedatives. Buspirone is used for the short-term relief of excessive anxiety in people with generalized anxiety disorder. It is not intended for everyday anxiety and stress. Generalized anxiety disorder is believed to be caused by imbalances in certain brain chemicals, and buspirone works by bringing these chemicals back into balance. Unlike benzodiazepines, buspirone does not have hypnotic, muscle relaxant, or anticonvulsant effects. It also does not cause physical dependence or withdrawal symptoms, which makes it a useful option for people who cannot take benzodiazepines. Buspirone is not effective for panic disorder, obsessive-compulsive disorder, or social anxiety disorder. It is also not used to treat anxiety that is caused by a medical condition or substance use.

Basic Buspar Information

• INN (International Nonproprietary Name): Buspirone hydrochloride
• Brand names available in Canada: Buspar® (original brand); generics include Apo-Buspirone (Apotex Inc.), Auro-Buspirone (Auro Pharma Inc.), AMB-Buspirone (Ambicare Pharmaceuticals Inc.), Jamp Buspirone (Jamp Pharma Corporation), Mint-Buspirone (Mint Pharmaceuticals Inc.), pms-Buspirone (Pharmascience Inc.), Teva-Buspirone (Teva Canada Limited), and Buspirone-10 (Pro Doc Limitée)
• ATC Code: N05BE01
• Forms and dosages: Scored tablets – 5 mg and 10 mg
• Manufacturers in Canada: Apotex Inc., Auro Pharma Inc., Ambicare Pharmaceuticals Inc., Jamp Pharma Corporation, Mint Pharmaceuticals Inc., Pharmascience Inc., Teva Canada Limited, and Pro Doc Limitée
• Registration status in Canada: Approved by Health Canada. Multiple DINs exist, including 02550555 (AMB-Buspirone 10 mg, Ambicare), 02211076 (Apo-Buspirone 10 mg, Apotex), 02500213 (Auro-Buspirone 10 mg, Auro Pharma), 02509911 (Jamp Buspirone 10 mg, Jamp Pharma), 02519054 (Mint-Buspirone 10 mg, Mint Pharmaceuticals), 02230942 (pms-Buspirone 10 mg, Pharmascience), 02231492 (Teva-Buspirone 10 mg, Teva Canada), and 02223163 (Buspirone-10, Pro Doc). Several older DINs, including 02207664 (Apotex 5 mg) and 02232564 (DOM-Buspirone), have been cancelled after market
• OTC / Rx classification: Prescription only (Rx) – not legally sold over-the-counter in Canadian pharmacies

Dosage & Direction

Take Buspar exactly as your doctor prescribes. The recommended starting dose is 5 mg two or three times daily. Your doctor may increase the dose by 5 mg every 2 to 3 days, up to a maximum of 45 mg daily in divided doses. In clinical studies, the effective dose ranged from 15 mg to 60 mg per day, but doses above 45 mg per day were not found to be more effective. Take the tablet with or without food. If it upsets your stomach, take it with a meal. Swallow the tablet whole with water. Do not crush or chew it. Try to take your doses at the same times each day. If you are taking buspirone for anxiety, it may take two to four weeks before you notice a real difference. Do not stop taking the medication suddenly without talking to your doctor, even if you feel better. Stopping abruptly is not known to cause withdrawal symptoms, but your anxiety may return. If you have kidney or liver problems, your doctor will start you on a lower dose and raise it more slowly. If you are elderly, your doctor may also start you on a lower dose. If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed one and continue with your regular schedule. Do not take two doses at once to make up for a missed one.

Precautions

Buspirone can cause dizziness and drowsiness, especially when you first start taking it or when your dose is increased. Until you know how it affects you, do not drive, operate heavy machinery, or do anything else that requires you to be alert. These effects may fade with time, but some people continue to feel drowsy. Taking buspirone with alcohol or other central nervous system depressants can increase the sedative effect and make drowsiness and dizziness worse. Avoid alcohol and check with your doctor before taking other medications that cause drowsiness, such as benzodiazepines, opioids, or antihistamines. Buspirone does not prevent withdrawal symptoms from benzodiazepines and is not a substitute for benzodiazepine tapering. If you are trying to stop a benzodiazepine, your doctor will give you a specific tapering schedule. Do not use buspirone to self-treat benzodiazepine withdrawal. Tell your doctor if you have a history of kidney or liver disease, because buspirone is processed by the liver and cleared by the kidneys. Your doctor may need to adjust your dose. If you have a seizure disorder or a history of seizures, tell your doctor before taking buspirone. The medication should be used with caution in people with a history of seizures. Buspirone is not recommended during pregnancy unless the benefit clearly outweighs the risk. It is not known whether buspirone passes into breast milk, so breastfeeding is not recommended without medical advice. Women who could become pregnant should discuss the risks and benefits with their doctor. Buspirone has not been studied in children under 18 years of age, so it should not be used in that age group unless specifically prescribed by a specialist. If you have phenylketonuria, tell your doctor before taking buspirone, as some formulations may contain aspartame. Buspirone can cause a condition called serotonin syndrome when taken with other serotonergic drugs. Symptoms include agitation, confusion, rapid heartbeat, muscle rigidity, and sweating. This is a medical emergency. If you experience any of these symptoms, stop the medication and seek immediate medical attention. Buspirone may also cause a rare but serious condition called tardive dyskinesia, which causes involuntary movements of the tongue, lips, face, and sometimes the limbs. The risk increases with longer treatment and higher total doses. If you develop any abnormal movements, tell your doctor right away.

Contraindications

Do not take Buspar if you have had an allergic reaction to buspirone or any of the inactive ingredients in the tablet. The medication is contraindicated in patients taking monoamine oxidase inhibitors (MAOIs), including phenelzine, tranylcypromine, and moclobemide. Do not start an MAOI within 14 days of stopping buspirone, and do not start buspirone within 14 days of stopping an MAOI. This combination can cause a life-threatening condition called serotonin syndrome. Buspirone is contraindicated in patients with severe kidney impairment. It should not be used in patients with severe liver impairment. Do not take buspirone if you have a history of severe allergic reactions to other medications in the same class. Buspirone is not recommended for use during pregnancy or breastfeeding unless specifically directed by a doctor. The safety and effectiveness of buspirone in children under 18 years of age have not been established. Do not use buspirone to treat anxiety that is caused by a medical condition or substance use.

Possible Side Effects

More than 1 in 10 people experience dizziness, drowsiness, nervousness, headache, and nausea. These are the most common side effects and are often most noticeable when starting treatment or increasing the dose. Other common side effects include dry mouth, blurred vision, constipation, diarrhea, and unusual tiredness. Some people notice decreased sexual ability or interest. These effects may fade as your body adjusts, but if they persist or bother you, tell your doctor. Serious side effects require immediate medical attention. Serotonin syndrome presents with agitation, confusion, rapid heartbeat, muscle rigidity, and sweating. Tardive dyskinesia causes involuntary movements of the face, tongue, or limbs. Severe allergic reactions, including rash, hives, swelling of the face or throat, and difficulty breathing, need emergency care. Falls and fractures have been reported in older adults taking buspirone, especially those who are also taking other medications that cause drowsiness. If you feel dizzy or unsteady, sit or lie down until the feeling passes. Buspirone can also cause a condition called akathisia, a feeling of inner restlessness that can be very uncomfortable. If you develop any of these serious effects, stop the medication and seek medical help right away. Most side effects from buspirone are mild and manageable, but any symptom that concerns you should be reported to your doctor.

Drug Interaction

Buspirone is metabolized mainly by the liver enzyme CYP3A4, so drugs that affect this enzyme can change its levels. Strong CYP3A4 inhibitors, such as ketoconazole, itraconazole, clarithromycin, and ritonavir, can increase buspirone levels and raise the risk of side effects. If you take one of these, your doctor may need to lower your buspirone dose. Strong CYP3A4 inducers, such as rifampin, carbamazepine, phenytoin, and St. John's wort, can lower buspirone levels and make it less effective. If you take one of these, your doctor may need to increase your buspirone dose. Grapefruit juice inhibits CYP3A4 and can raise buspirone levels. Avoid large amounts of grapefruit juice during treatment. Buspirone should not be taken with MAO inhibitors, including phenelzine, tranylcypromine, and moclobemide, because of the risk of serotonin syndrome. Do not take buspirone with other serotonergic drugs, including SSRIs (such as fluoxetine, paroxetine, sertraline), SNRIs (such as venlafaxine, duloxetine), tricyclic antidepressants (such as amitriptyline, nortriptyline), trazodone, triptans, fentanyl, tramadol, and St. John's wort. These combinations can increase the risk of serotonin syndrome. Buspirone can interact with haloperidol, increasing its levels and the risk of side effects. It may also interact with nefazodone, trazodone, and diazepam. Buspirone can add to the sedative effects of alcohol, benzodiazepines, opioids, and other central nervous system depressants. Tell your doctor and pharmacist about every medication you take, including over-the-counter products, vitamins, and herbal supplements.

Missed Dose

If you miss a dose of Buspar, take it as soon as you remember. If it is almost time for your next dose, skip the missed one and continue with your regular schedule. Do not take two doses at once to make up for a missed one. If you miss several doses in a row, contact your doctor before restarting. Your anxiety may return if you miss doses, so try to take the medication at the same times each day.

Overdose

Overdose with buspirone is not common, but it can cause nausea, vomiting, dizziness, drowsiness, and a fast heartbeat. In severe cases, it may cause low blood pressure, fainting, and confusion. There is no specific antidote. Treatment is supportive and may include activated charcoal if the overdose was recent, intravenous fluids, and monitoring of vital signs. Contact a poison control centre or go to an emergency department if you or someone else has taken more than the prescribed dose. Do not try to manage an overdose at home.

Storage

Store Buspar tablets at room temperature between 15 and 30 degrees Celsius (59 and 86 degrees Fahrenheit). Keep the container tightly closed and protect it from light and moisture. Do not store in the bathroom or near a sink. Keep out of reach of children and pets. Do not use after the expiry date on the label. Dispose of unused medication according to local guidelines. Do not flush buspirone down the toilet or pour it down the sink.

Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

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