Generic Efudex ( Fluorouracil )

Buy cheap Generic Efudex (Fluorouracil ) without dr prescription at Canadian Pharmacy

At our US pharmacy, you can purchase Efudex (fluorouracil) 5% cream without a prescription, with discreet and anonymous packaging delivered within 5-14 days across USA.
Efudex is a topical chemotherapy cream used to treat actinic keratosis, a rough, scaly patch on the skin caused by years of sun exposure. It is also used for superficial basal cell carcinoma, the most common form of skin cancer, when surgery is not practical or when there are multiple lesions. The active ingredient, fluorouracil, kills abnormal skin cells by blocking their ability to make DNA.
The 5% cream is applied twice daily for 2 to 6 weeks, depending on what is being treated. A 1% cream existed in Canada under the brand name Fluoroplex, but it is no longer manufactured or sold here.
The administration form is a topical cream, supplied in 40 g tubes for the 5% strength.
The medication starts working within days, but the visible reaction, redness, peeling, and crusting, usually peaks around two to four weeks.
Alcohol consumption is not a concern with this topical product, as systemic absorption through intact skin is minimal.
The most common side effects are local skin reactions: redness, burning, stinging, and soreness at the application site.
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Common Use Efudex

Fluorouracil is an antimetabolite that looks like uracil, one of the building blocks of RNA. The enzyme thymidylate synthase mistakes it for the real thing and gets blocked. Without that enzyme working, the cell cannot make thymidine, which it needs for DNA. Fast-dividing abnormal cells, the kind found in sun-damaged skin, take up fluorouracil more readily than healthy skin cells, so they die first. The skin then sheds those dead cells and replaces them with healthier tissue. Efudex 5% is approved in Canada for premalignant keratoses and superficial basal cell carcinoma. It is not meant for deep, nodular, or penetrating skin cancers, which usually do not respond to topical therapy. It also is not used for actinic keratosis on the back of the hands, though some doctors prescribe it off-label for that area.

Basic Efudex Information

• INN (International Nonproprietary Name): Fluorouracil
• Brand names available in Canada: Efudex®; the 1% cream was sold as Fluoroplex® but is no longer manufactured for the Canadian market. Tolak® (4% fluorouracil sodium cream) is a different formulation approved for actinic keratosis of the face, ears, and scalp.
• ATC Code: L01BC02
• Forms and dosages: Cream, 5% w/w (50 mg fluorouracil per gram), supplied in 40 g tubes. A 1% cream (Fluoroplex) and 2% and 5% solutions also existed historically but are not currently marketed in Canada.
• Manufacturers in Canada: Bausch Health, Canada Inc. (Laval, Quebec) holds DIN 00330582 for Efudex 5% cream.
• Registration status in Canada: Approved by Health Canada. DIN 00330582 is currently marketed.
• OTC / Rx classification: Prescription only (Rx) – not legally sold over-the-counter in Canadian pharmacies

Dosage & Direction

Wash the area with mild soap and water, then pat it dry. Wait about 10 minutes before applying the cream. Use a nonmetal applicator, a cotton swab, or a gloved finger to put a thin film over each lesion. Do not rub it in vigorously. If you use your bare finger, wash your hands right away afterward. For actinic keratosis, apply Efudex 5% twice daily for 2 to 4 weeks. Some doctors extend treatment to 6 weeks if the lesions are thick. For superficial basal cell carcinoma, apply twice daily for 3 to 6 weeks, and in some cases up to 10 to 12 weeks. The goal is to continue until the skin reaches the erosion stage, meaning it becomes raw and weepy. At that point, stop the cream and let the skin heal. Complete healing can take one to two months after you stop. Do not cover the treated area with an occlusive dressing unless your doctor tells you to. If you miss a dose, apply it as soon as you remember, unless it is almost time for the next one. Then skip the missed dose and go back to your regular schedule.

Precautions

Efudex is a strong medication, and the skin reaction it causes is expected, not a sign that something is wrong. The treated area will become red, then sore, then crusty or weepy. That is the drug working. But if the reaction is severe, if you develop blisters, or if the pain keeps you from sleeping, call your doctor. Do not use Efudex on broken skin, on mucous membranes, or near the eyes, nose, or mouth. If you get some in your eye, rinse with plenty of water and call your doctor. Fluorouracil can be absorbed through the skin, especially if it is applied to a large area or to skin that is already damaged. This means systemic side effects are possible, though they are rare with proper use. People with a condition called dihydropyrimidine dehydrogenase (DPD) deficiency cannot break down fluorouracil normally, and life-threatening toxicity has been reported in such patients after topical use. Efudex is not for use during pregnancy or breastfeeding. Women who could become pregnant should use effective contraception during treatment. Safety and effectiveness in children under 18 have not been established. Avoid prolonged sun exposure during treatment, and use sunscreen on other areas of skin.

Contraindications

Do not use Efudex if you have had an allergic reaction to fluorouracil or any of the inactive ingredients in the cream. It is contraindicated during pregnancy and while breastfeeding. It must not be used in patients with known DPD enzyme deficiency, because the drug can build up to dangerous levels. Efudex should not be used together with brivudine, an antiviral medication, because that combination can cause severe and potentially fatal fluorouracil toxicity. The cream is not for ophthalmic, oral, or intravaginal use. Do not apply it to mucous membranes or to the eyelids. Efudex has not been studied in children, so it should not be used in patients under 18 years of age.

Possible Side Effects

The expected reaction is local and temporary: redness, burning, stinging, soreness, and itching where the cream is applied. As treatment continues, the skin may blister, peel, crust, and weep. This is the inflammatory response that clears the abnormal cells. Some people also develop a rash, dry skin, or changes in skin color. Scarring is uncommon but can happen, especially if the treated area becomes infected. Tell your doctor if you notice pus, increased warmth, or a foul odor, as those could be signs of infection. Rarely, fluorouracil can cause allergic contact dermatitis, a more widespread itchy rash. Systemic side effects from topical use are uncommon but include nausea, vomiting, diarrhea, and low blood cell counts. These are more likely if you apply the cream to a large area or use it for a long time. Stop the medication and call your doctor if you feel unusually tired, develop a fever, or have severe stomach symptoms.

Drug Interaction

Efudex has one major drug interaction: brivudine. Do not take brivudine while using Efudex, and wait at least 4 weeks after stopping brivudine before you start fluorouracil. Other than that, topical fluorouracil is not known to interact significantly with medications taken by mouth. It is not expected to affect the way your liver processes other drugs, because systemic absorption is low when it is used correctly. Still, tell your doctor and pharmacist about every medication you take, including over-the-counter products and supplements, especially if you take any antiviral medication. If you are using other topical products on the same area, check with your doctor before combining them.

Missed Dose

If you forget to apply Efudex, put it on as soon as you remember. If it is almost time for your next dose, skip the missed one and continue with your regular schedule. Do not apply extra cream to make up for a missed dose. Consistency matters for topical chemotherapy because the drug needs to be present on the skin regularly to keep killing abnormal cells.

Overdose

Overdose with topical Efudex is unlikely to cause serious harm if you have applied too much to a small area. You may get a stronger skin reaction than expected, with more redness, pain, and peeling. If you swallow the cream, it can cause nausea, vomiting, diarrhea, and in severe cases, bone marrow suppression or gastrointestinal ulceration. Contact a poison control centre or go to an emergency department if someone ingests Efudex. Do not induce vomiting unless a healthcare professional tells you to.

Storage

Store Efudex cream at room temperature between 15 and 30 degrees Celsius (59 and 86 degrees Fahrenheit). Keep the tube tightly closed when not in use. Do not freeze. Protect it from light and moisture. Do not store it in the bathroom or near a sink. Keep out of reach of children and pets. Do not use after the expiry date on the tube. Dispose of unused cream according to local guidelines.

Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

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