Generic Sertraline

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At our US pharmacy, you can purchase Sertraline 25 mg, 50 mg, and 100 mg capsules without a prescription, with discreet and anonymous packaging delivered within 5-14 days across USA.
Sertraline is a selective serotonin reuptake inhibitor (SSRI) used to treat depression, obsessive-compulsive disorder, panic disorder, and post-traumatic stress disorder. It is also commonly prescribed for social anxiety disorder and generalized anxiety disorder. The medication works by increasing the amount of serotonin in the brain, which helps improve mood and emotional balance.
The usual starting dose for adults is 50 mg once daily. Your doctor may increase the dose by 50 mg at weekly intervals if needed, up to a maximum of 200 mg per day. For panic disorder, the starting dose is often 25 mg once daily for the first week, then increased to 50 mg daily. Children aged 6 to 12 years start at 25 mg daily for OCD, with a maximum of 200 mg per day.
The administration form is hard gelatin capsules in 25 mg (yellow), 50 mg (white and yellow), and 100 mg (orange) strengths. Take the capsule with food to increase absorption and reduce stomach upset.
Sertraline does not work overnight. Improvements in sleep, appetite, and energy may appear within the first two weeks, but the full benefit for depression or anxiety usually takes four to six weeks of steady dosing. Do not stop taking it just because you do not feel better in the first few days.
Alcohol should be avoided during treatment. It can increase the drowsiness and dizziness that sertraline can cause, and it may worsen some of the side effects of the medication.
The most common side effects are headache, nausea, diarrhea, dry mouth, sweating, and tremor. Sexual side effects such as decreased desire or difficulty reaching orgasm are also common.
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Common Use Sertraline

Sertraline is a selective serotonin reuptake inhibitor. It works by blocking the reuptake of serotonin at nerve endings, which increases its availability in the spaces between nerve cells. This is thought to improve mood and reduce anxiety. Health Canada has approved sertraline for the symptomatic relief of depressive illness, panic disorder with or without agoraphobia, and obsessive-compulsive disorder. The Notice of Compliance for Zoloft 50 mg (DIN 01962817) and 100 mg (DIN 01962779) was granted on January 30, 1992, with the 25 mg strength (DIN 02132702) approved later. Sertraline is also used off-label for social anxiety disorder, post-traumatic stress disorder, and premenstrual dysphoric disorder. It is not approved for use in children under 6 years of age.

Basic Sertraline Information

• INN (International Nonproprietary Name): Sertraline hydrochloride
• Brand names available in Canada: Zoloft® (BGP Pharma ULC, a Viatris company, DIN 01962817 for 50 mg, DIN 01962779 for 100 mg, DIN 02132702 for 25 mg); generics include Apo-Sertraline (Apotex Inc.), Teva-Sertraline (Teva Canada Limited, DIN 02240484 for 50 mg, DIN 02240485 for 25 mg, DIN 02240481 for 100 mg), Sandoz Sertraline (Sandoz Canada Inc.), pms-Sertraline (Pharmascience Inc.), Pro-Sertraline (Pro Doc Limitée, DIN 02241303 for 50 mg, DIN 02241304 for 100 mg, DIN 02241302 for 25 mg), Jamp Sertraline (Jamp Pharma Corporation, DIN 02469634 for 50 mg), Sanis Sertraline (Sanis Health Inc., DIN 02353520 for 25 mg, DIN 02353539 for 50 mg, DIN 02353547 for 100 mg), Sivem Sertraline (Sivem Pharmaceuticals ULC, DIN 02386070 for 25 mg, DIN 02386089 for 50 mg, DIN 02386097 for 100 mg), Riva-Sertraline (Laboratoire Riva Inc., DIN 02248496 for 25 mg, DIN 02248497 for 50 mg, DIN 02248498 for 100 mg), Auro-Sertraline (Auro Pharma Inc.), Mar-Sertraline (Marcan Pharmaceuticals Inc.), Mint-Sertraline (Mint Pharmaceuticals Inc.), and NRA-Sertraline (Nora Pharma Inc.).
• ATC Code: N06AB06
• Forms and dosages: Capsules – 25 mg, 50 mg, and 100 mg. A concentrated oral solution (20 mg/mL) is available in some markets.
• Manufacturers in Canada: BGP Pharma ULC (Zoloft), Apotex Inc. (Apo-Sertraline), Teva Canada Limited (Teva-Sertraline), Sandoz Canada Inc. (Sandoz Sertraline), Pharmascience Inc. (pms-Sertraline), Pro Doc Limitée (Pro-Sertraline), Jamp Pharma Corporation (Jamp Sertraline), Sanis Health Inc. (Sanis Sertraline), Sivem Pharmaceuticals ULC (Sivem Sertraline), Laboratoire Riva Inc. (Riva-Sertraline), Auro Pharma Inc. (Auro-Sertraline), Marcan Pharmaceuticals Inc. (Mar-Sertraline), Mint Pharmaceuticals Inc. (Mint-Sertraline), and Nora Pharma Inc. (NRA-Sertraline).
• Registration status in Canada: Approved by Health Canada. Multiple DINs exist for the brand and generic products. Zoloft 25 mg (DIN 02132702), 50 mg (DIN 01962817), and 100 mg (DIN 01962779) are marketed by BGP Pharma ULC. Generic sertraline capsules are available under numerous DINs, including 02240484 (Teva-Sertraline 50 mg, marketed since 2010-11-13), 02240485 (Teva-Sertraline 25 mg, marketed since 2010-11-13), 02241303 (Pro-Sertraline 50 mg), 02241304 (Pro-Sertraline 100 mg), 02353520 (Sanis Sertraline 25 mg, marketed since 2022-06-21), 02353539 (Sanis Sertraline 50 mg), 02353547 (Sanis Sertraline 100 mg), 02469634 (Jamp Sertraline 50 mg), 02248496 (Riva-Sertraline 25 mg), 02248497 (Riva-Sertraline 50 mg), 02248498 (Riva-Sertraline 100 mg), 02386070 (Sivem Sertraline 25 mg), 02386089 (Sivem Sertraline 50 mg), and 02386097 (Sivem Sertraline 100 mg). A 2025 recall affected one lot of Jamp Sertraline 50 mg (DIN 02469634) because bottles may have contained 25 mg capsules. A Notice of Compliance was granted to Altamed Pharma on 2023-04-20 for a generic sertraline capsule, referencing Zoloft as the Canadian reference product.
• OTC / Rx classification: Prescription only (Rx) – not legally sold over-the-counter in Canadian pharmacies

Dosage & Direction

Take Sertraline exactly as your doctor prescribes. The dose depends on what is being treated. For depression and obsessive-compulsive disorder in adults, the recommended starting dose is 50 mg once daily, taken with food. Your doctor may increase the dose by 50 mg at weekly intervals if needed. The usual maintenance range is 50 mg to 200 mg per day. For panic disorder, the recommended starting dose is 25 mg once daily for the first week, then increased to 50 mg once daily. The maximum dose is 200 mg per day. For children aged 6 to 12 years with OCD, the starting dose is 25 mg once daily, with increases of 25 mg at weekly intervals as needed, up to a maximum of 200 mg per day. For adolescents aged 13 to 17 with OCD, the starting dose is 50 mg once daily. Take the capsule with food to increase absorption and reduce gastrointestinal side effects. Swallow the capsule whole with water. Do not open, crush, or chew it. If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed one and continue with your regular schedule. Do not take two doses at once. Do not stop taking Sertraline suddenly without talking to your doctor. Stopping abruptly can cause discontinuation syndrome, with symptoms such as dizziness, tingling, sleep disturbances, agitation, anxiety, nausea, and vomiting. Your doctor will taper the dose gradually over at least one to two weeks, or longer if needed, to reduce the risk of withdrawal effects.

Precautions

Sertraline carries a boxed warning about an increased risk of suicidal thoughts and behaviours in pediatric and young adult patients taking antidepressants. Close monitoring is required, especially during the first few weeks of treatment or after dose changes. If you or someone you care for notices worsening mood, new or increased thoughts of self-harm, or unusual behaviour changes, get help immediately. Sertraline can cause serotonin syndrome, a potentially life-threatening condition caused by too much serotonin in the body. The risk is higher when sertraline is taken with other serotonergic drugs, including MAO inhibitors, other SSRIs, SNRIs, triptans, tramadol, and St. John's wort. Symptoms include agitation, confusion, rapid heartbeat, muscle rigidity, and sweating. Stop the medication and seek emergency care if these occur. Sertraline can increase the risk of bleeding, especially when taken with aspirin, NSAIDs, warfarin, or other anticoagulants. Tell your doctor if you take any of these medications. The medication can cause hyponatremia (low sodium in the blood), especially in older adults and people taking diuretics. Symptoms include headache, difficulty concentrating, memory problems, confusion, and weakness. Sertraline can cause angle-closure glaucoma in patients with untreated anatomically narrow angles. Tell your doctor if you have a history of glaucoma. Sertraline can cause QT prolongation, a change in heart rhythm. Use with caution if you have heart disease or take other drugs that affect heart rhythm. Sertraline should be used with caution in patients with a history of seizures. The medication can cause drowsiness and dizziness. Do not drive or operate heavy machinery until you know how it affects you. Sertraline is not recommended during pregnancy unless the benefit clearly outweighs the risk. It is one of the most studied antidepressants in pregnancy, and it is often considered a first-line choice when medication is needed. It passes into breast milk in small amounts, and most reports show no problems for babies exposed through breast milk. Women who could become pregnant should discuss the risks and benefits with their doctor. Sertraline should not be used in children under 6 years of age. Older adults may be more sensitive to the side effects and may need lower doses. Tell your doctor if you have liver or kidney problems, as dose adjustments may be needed. Bone fractures have been reported with this class of medication.

Contraindications

Do not take Sertraline if you have had an allergic reaction to sertraline or any of the inactive ingredients in the capsule. Sertraline is contraindicated in patients taking monoamine oxidase inhibitors (MAOIs), including phenelzine, tranylcypromine, and moclobemide. Do not start an MAOI within 14 days of stopping sertraline, and do not start sertraline within 14 days of stopping an MAOI. This combination can cause a life-threatening condition called serotonin syndrome. Sertraline is contraindicated in patients taking pimozide, an antipsychotic medication, because the combination can cause serious heart rhythm problems. Do not take sertraline if you have a history of angle-closure glaucoma. Sertraline should not be used during pregnancy or breastfeeding unless specifically directed by a doctor. Do not take sertraline if you have severe liver impairment. If you are unsure whether any of these apply to you, check with your doctor or pharmacist.

Possible Side Effects

More than 10% of people experience headache (22%), insomnia (21%), diarrhea (11%), and nausea (15%). Other common side effects include dry mouth, fatigue, dizziness, decreased appetite, increased sweating, and tremor. Sexual side effects such as decreased libido or difficulty reaching orgasm are common but often not discussed. In the treatment of social anxiety disorder, ejaculation failure occurred in 14% of men taking sertraline compared to 0% with placebo. These effects are often most noticeable when starting treatment or increasing the dose, and they may fade as your body adjusts. Serious side effects require immediate medical attention. Serotonin syndrome presents with agitation, confusion, rapid heartbeat, muscle rigidity, and sweating. Hyponatremia can cause headache, confusion, and weakness. Angle-closure glaucoma presents with sudden eye pain, blurred vision, and redness. Increased bleeding risk can cause easy bruising or unusual bleeding. Severe allergic reactions, including rash, hives, swelling of the face or throat, and difficulty breathing, need emergency care. If you develop any of these serious effects, stop the medication and seek medical help right away. Antidepressants, including Sertraline, may increase suicidal thoughts or behaviour, especially in young people. If you notice worsening mood or new thoughts of self-harm, contact your doctor immediately. Discontinuation syndrome can occur if the medication is stopped suddenly, causing dizziness, tingling, sleep disturbances, agitation, anxiety, nausea, and vomiting.

Drug Interaction

Sertraline interacts with several medications. MAO inhibitors are strictly contraindicated and must not be used with sertraline. Pimozide is also contraindicated because the combination can cause serious heart rhythm problems. Other serotonergic drugs, including other SSRIs, SNRIs, tricyclic antidepressants, triptans, fentanyl, tramadol, and St. John's wort, can increase the risk of serotonin syndrome. Drugs that affect bleeding, such as aspirin, NSAIDs, warfarin, and other anticoagulants, can increase the risk of bleeding when taken with sertraline. Sertraline is a weak inhibitor of CYP2D6, so it can increase the levels of drugs metabolized by this enzyme, including certain antidepressants, antipsychotics, beta-blockers, and opioids. If you take one of these, your doctor may need to adjust the dose. Cimetidine can inhibit the metabolism of sertraline and raise its levels. Warfarin levels may be affected, and prothrombin time should be monitored closely if you take both. Sertraline can also interact with diuretics, increasing the risk of hyponatremia. Grapefruit juice should be avoided, as it may increase sertraline levels in the body. Tell your doctor and pharmacist about every medication you take, including over-the-counter products, vitamins, and herbal supplements.

Missed Dose

If you miss a dose of Sertraline, take it as soon as you remember. If it is almost time for your next dose, skip the missed one and continue with your regular schedule. Do not take two doses at once to make up for a missed one. If you miss several doses in a row, contact your doctor before restarting. Missing doses can cause your symptoms to return, so try to take the medication at the same time each day.

Overdose

Overdose with Sertraline can cause drowsiness, nausea, vomiting, fast heart rate, and tremor. In severe cases, it can cause serotonin syndrome, seizures, and changes in heart rhythm. There is no specific antidote. Treatment is supportive and may include activated charcoal if the overdose was recent, intravenous fluids, and monitoring of vital signs. Contact a poison control centre or go to an emergency department immediately if you or someone else has taken too much. Do not try to manage an overdose at home.

Storage

Store Sertraline capsules at room temperature between 15 and 30 degrees Celsius (59 and 86 degrees Fahrenheit). Keep the container tightly closed and protect it from light and moisture. Do not store in the bathroom or near a sink. Keep out of reach of children and pets. Do not use after the expiry date on the label. Dispose of unused medication according to local guidelines. Do not flush sertraline down the toilet or pour it down the sink.

Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

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