Generic Valparin ( Valproic Acid )

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At our US pharmacy, you can purchase Valparin (valproic acid) 250 mg, 500 mg, and 750 mg delayed-release tablets without a prescription, with discreet and anonymous packaging delivered within 5-14 days across USA.
Valparin is an anticonvulsant and mood stabilizer used to treat epilepsy, manic episodes associated with bipolar disorder, and to prevent migraine headaches. It works by increasing the levels of GABA, a calming chemical in the brain, which helps reduce abnormal electrical activity that causes seizures and mood swings.
The usual starting dose for adults is 600 mg daily in divided doses. Your doctor may increase the dose by 200 mg every three days until the desired effect is achieved. The usual maintenance range is 1,000 mg to 2,000 mg per day, though some people need up to 2,500 mg daily under close supervision. For seizure control, the starting dose is 10 to 15 mg/kg per day, titrated up to 20 to 30 mg/kg per day.
The administration form is enteric-coated or controlled-release tablets in 200 mg, 500 mg, and 750 mg strengths. Valparin Chrono allows once-daily dosing. An oral solution is also available for children and people who have trouble swallowing tablets.
Valparin does not work overnight. It may take several weeks of steady dosing before you notice the full benefit for seizures, mood stabilization, or migraine prevention. Do not stop taking it just because you do not feel an effect in the first few days.
Alcohol should be avoided during treatment. It adds to the drowsiness and dizziness that Valparin can cause, and it can increase the risk of liver damage and pancreatitis.
The most common side effects are nausea, vomiting, diarrhea, abdominal pain, and increased appetite. Weight gain, hair loss, and tremor are also common with this medication.
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Common Use Valparin

Valproic acid is a carboxylic acid derivative with broad-spectrum antiepileptic activity. It works by increasing the levels of gamma-aminobutyric acid (GABA), the brain's main inhibitory neurotransmitter. This dampens the excessive electrical activity that causes seizures. It may also block voltage-gated sodium channels and affect the metabolism of certain neurotransmitters. Valparin is indicated for the treatment of generalized or partial epilepsy, including absence, myoclonic, tonic-clonic, atonic, and mixed seizures, as well as specific syndromes such as West and Lennox-Gastaut. It is also used for the treatment of manic episodes associated with bipolar disorders. In children and adolescents under 18 years, the efficacy for treating manic episodes in bipolar disorder has not been established. Valparin is not approved for use in children under 2 years of age for epilepsy due to an increased risk of fatal hepatotoxicity, and it should not be used to prevent migraine headaches in pregnant women or women of childbearing potential who are not using effective contraception.

Basic Valparin Information

• INN (International Nonproprietary Name): Valproic acid (also known as valproate sodium or divalproex sodium)
• Brand names available in Canada: Valparin® is not marketed in Canada. In Canada, valproic acid is sold under the brand name Depakene® (BGP Pharma ULC) and generics including Apo-Valproic Acid, Teva-Valproic Acid, Sandoz Valproic Acid, pms-Valproic Acid, and others. Divalproex sodium is sold as Epival® (BGP Pharma ULC) and generics including Apo-Divalproex, Teva-Divalproex, and others.
• ATC Code: N03AG01
• Forms and dosages: Enteric-coated or controlled-release tablets – 200 mg, 500 mg, and 750 mg. Oral solution – 200 mg/5 mL. In Canada, delayed-release tablets are available in 250 mg, 500 mg, and 750 mg strengths.
• Manufacturers in Canada: BGP Pharma ULC (Depakene, Epival), Apotex Inc. (Apo-Valproic Acid, Apo-Divalproex), Teva Canada Limited (Teva-Valproic Acid, Teva-Divalproex), Sandoz Canada Inc. (Sandoz Valproic Acid), Pharmascience Inc. (pms-Valproic Acid, pms-Divalproex), and others. Valparin is manufactured by Torrent Pharmaceuticals Ltd. (India) for markets outside Canada.
• Registration status in Canada: Valproic acid is approved by Health Canada under multiple DINs, including 02238069 (Valproic Acid Oral Solution, Apotex), 00596434 (Epival 500 mg, BGP Pharma), and 02140047 (Ratio-Valproic 250 mg, Teva Canada). Valparin itself is not approved by Health Canada and is not marketed in Canada. The product is available in other countries and can be sourced through international channels.
• OTC / Rx classification: Prescription only (Rx) – not legally sold over-the-counter in Canadian pharmacies

Dosage & Direction

Take Valparin exactly as your doctor prescribes. The dose depends on what is being treated, your age, and your body weight. For seizure control in adults, the initial daily dosage is 10 to 15 mg/kg, titrated up to 20 to 30 mg/kg. Careful monitoring is required when receiving daily doses higher than 50 mg/kg. Valparin Chrono allows once-daily dosing. For treating mania, the initial dosage is 600 mg daily, increased by 200 mg per day at three-day intervals. The usual range is 1,000 to 2,000 mg per day. When control is not achieved, the dose may be further increased to 2,500 mg per day. For children, the dose is 20 to 50 mg/kg body weight in divided doses. The oral solution is more appropriate for children under 11 years. Take the tablet with food or milk to reduce stomach upset. Swallow the tablet whole. Do not crush or chew it, because the enteric coating protects your stomach from irritation. If you are taking the oral solution, use the measuring device provided. Do not use a household spoon. If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed one and continue with your regular schedule. Do not take two doses at once. Do not stop taking Valparin suddenly without talking to your doctor. Stopping abruptly can cause seizures to return or mood symptoms to worsen. Your doctor will taper the dose gradually over weeks or months.

Precautions

Valproic acid carries a boxed warning about life-threatening adverse reactions, including hepatotoxicity, pancreatitis, and fetal risk. Hepatotoxicity, including fatalities, usually occurs during the first 6 months of treatment. Children under the age of two years and patients with mitochondrial disorders are at higher risk. Your doctor should check your liver function before you start treatment and at frequent intervals thereafter. Call your doctor right away if you develop signs of liver problems like dark urine, tiredness, decreased appetite, upset stomach or stomach pain, light-colored stools, vomiting, or yellow skin or eyes. Pancreatitis, including fatal hemorrhagic cases, has been reported with valproic acid. Stop the medication and seek medical attention if you develop severe abdominal pain, nausea, vomiting, or loss of appetite. Valproic acid can cause serious skin reactions, including Stevens-Johnson syndrome and toxic epidermal necrolysis, which can be life-threatening. If you develop a rash, blisters, peeling skin, or sores in your mouth or eyes, stop the medication and get emergency care. Hyperammonemia, a buildup of ammonia in the blood, can occur with valproic acid, even when liver function tests are normal. Symptoms include unexplained drowsiness, vomiting, or changes in mental status. Your doctor may check your ammonia levels if these occur. Valproic acid can cause low body temperature (hypothermia), especially in older adults. Tell your doctor if you feel unusually cold or have difficulty staying warm. The medication can cause thrombocytopenia, a low platelet count, which increases the risk of bleeding. Your doctor should monitor your platelet count, especially before surgery. Valproic acid can cause weight gain and increased appetite. Your doctor should monitor your weight during treatment. It can also cause hair loss, which is usually temporary. Valproic acid is not recommended during pregnancy. It has a high teratogenic potential, and babies exposed in the womb have a high risk of congenital malformations and neurodevelopmental disorders. Women who could become pregnant should use effective contraception and discuss the risks with their doctor. It passes into breast milk, so breastfeeding is not recommended without medical advice. Valproic acid should not be used in children under 2 years of age for epilepsy due to an increased risk of fatal hepatotoxicity. Older adults may be more sensitive to the side effects of valproic acid and may need lower doses. Tell your doctor if you have kidney disease, liver disease, or a urea cycle disorder. Monitoring of signs and symptoms of ototoxicity is recommended during treatment.

Contraindications

Do not take Valparin if you have had an allergic reaction to valproic acid, divalproex sodium, or any of the inactive ingredients in the tablet or solution. Valparin is contraindicated in patients with hepatic disease or significant hepatic dysfunction. It should not be used in patients with known mitochondrial disorders caused by mutations in the nuclear gene encoding mitochondrial enzyme polymerase gamma (POLG), or in children under 2 years of age who are suspected of having a POLG-related disorder. Valparin is contraindicated in patients with known urea cycle disorders, because it can cause severe hyperammonemia. Do not use it in patients with known hypersensitivity to the drug. Valparin is contraindicated for the prophylaxis of migraine headaches in pregnant women and in women of childbearing potential who are not using effective contraception. It should not be used during pregnancy for epilepsy or bipolar disorder unless there is no suitable alternative treatment, and in women of childbearing potential unless the conditions of the pregnancy prevention program are fulfilled. Do not take Valparin if you have a history of pancreatitis. It is contraindicated in patients with hepatic porphyria. If you are unsure whether any of these apply to you, check with your doctor or pharmacist.

Possible Side Effects

More than 5% of people experience abdominal pain, hair loss, blurred vision, amnesia, anorexia, weakness, ataxia (loss of coordination), constipation, depression, diarrhea, dizziness, double vision, upset stomach, shortness of breath, bruising, emotional instability, fever, flu-like symptoms, headache, increased appetite, and infection. These effects are often most noticeable when starting treatment or increasing the dose. Some people notice tremor, weight gain, and changes in mood. These effects may fade as your body adjusts, but if they persist or bother you, tell your doctor. Serious side effects require immediate medical attention. Liver injury can cause jaundice, dark urine, and abdominal pain. Pancreatitis can cause severe stomach pain, nausea, and vomiting. Severe skin reactions can cause rash, blisters, peeling skin, and sores in the mouth or eyes. Hyperammonemia can cause confusion, drowsiness, and vomiting. Low platelet count can cause easy bruising or unusual bleeding. Hypothermia can cause shivering, confusion, and difficulty speaking. If you develop any of these serious effects, stop the medication and seek medical help right away. Antiepileptic drugs, including valproic acid, increase the risk of suicidal thoughts or behaviour. If you notice worsening mood or new thoughts of self-harm, contact your doctor immediately.

Drug Interaction

Valproic acid interacts with several medications. Pivalate-conjugated drugs, such as cefditoren pivoxil, adefovir dipivoxil, pivmecillinam, and pivampicillin, should be avoided with Valparin. Concurrent use of Valparin and clozapine can increase the risk of neutropenia and clozapine-induced myocarditis. Valproic acid inhibits the glucuronidation of zidovudine, which can increase its levels and toxicity. It can potentiate the effects of psychotropic drugs such as neuroleptics, MAO inhibitors, antidepressants, and benzodiazepines. Carbamazepine toxicity has been reported when used with valproic acid, as valproic acid can increase carbamazepine levels. Rifampicin can reduce valproic acid serum concentrations, and the dose may need adjustment. Salicylates should be avoided in children under 3 years of age due to the risk of liver toxicity. Valproic acid can increase the levels of lamotrigine, increasing the risk of a serious rash. Acetazolamide and valproic acid together can increase the risk of hyperammonemia and encephalopathy. Methotrexate can reduce valproic acid serum concentrations. Cimetidine, fluoxetine, and other drugs that inhibit liver metabolism can increase valproic acid levels. Valproic acid increases primidone plasma levels with exacerbation of its adverse effects such as sedation. It also increases the free form of phenytoin with possible overdose symptoms. Estrogen-containing products, including estrogen-based hormonal contraceptives, can increase the clearance of valproate, which may reduce its serum concentration and effectiveness. Tell your doctor and pharmacist about every medication you take, including over-the-counter products, vitamins, and herbal supplements.

Missed Dose

If you miss a dose of Valparin, take it as soon as you remember. If it is almost time for your next dose, skip the missed one and continue with your regular schedule. Do not take two doses at once to make up for a missed one. If you miss several doses in a row, contact your doctor before restarting. Missing doses can increase the risk of seizures or mood destabilization, so try to take the medication at the same times each day.

Overdose

Overdose with Valparin is a medical emergency. Massive overdose, in the range of 10 to 20 times the maximum therapeutic levels, causes serious central nervous system and respiratory depression. Symptoms include nausea, vomiting, dizziness, coma, muscle weakness, constricted pupils, breathing problems, seizures, and cerebral edema (swelling of the brain) with increased intracranial pressure. There is no specific antidote. Treatment is supportive and may include induced vomiting, gastric lavage, assisted ventilation, and other supportive measures. Full recovery is usual following treatment. Contact a poison control centre or go to an emergency department immediately if you or someone else has taken too much. Do not try to manage an overdose at home.

Storage

Store Valparin tablets at room temperature not exceeding 30 degrees Celsius (86 degrees Fahrenheit). Protect from light and moisture. Keep the container tightly closed and store it in a dry place. Do not store in the bathroom or near a sink. Keep out of reach of children and pets. Do not use after the expiry date on the label. Dispose of unused medication according to local guidelines. Do not flush Valparin down the toilet or pour it down the sink.

Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.

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